Simulation canvas
Live
Antigen match
90%
Surface CAR (TM)
94%
Best chassis
Tscm
Off-tumor risk
35%
Engagement stage
Cartoon synapse, kill pressure, and transmembrane readouts for the selected chassis.
Interactive
Active killing synapse
CAR scFv bound to tumor antigen; perforin/granzyme and cytokine programs active.
CAR-T · Tscm
Stem cell memory (Tscm)
≈ 8 surface CARs
Kill pressure
65%
scFv → CD19
Tumor · CD19
B-ALL
Membrane stress / apoptosis
Antigen match
90%
Target fit
Surface CAR
94%
CD8α TM
TM coupling
77%
Across membrane
TM stability
95%
Tonic load OK
Transmembrane effect
Stable clinical default. High surface CAR density, low tonic signaling, solid persistence.
Hinge: CD8α hingeCostim: 4-1BB (CD137)Dose: 10^6.5 cellsTonic load: 27%
CAR cassette (N → C)
Extra → intrascFv
CD19
Antigen binder
Hinge
CD8α
Spacer length
TM
CD8α
Membrane anchor
Costim
4-1BB
2nd signal
Signal
CD3ζ
CD3ζ ITAMs
TM note: Stable clinical default. High surface CAR density, low tonic signaling, solid persistence.
T-cell subtype ranking
Same CAR across eight starting phenotypes. Click a bar or row to focus the stage.
| Subtype | Score |
|---|---|
Tscm | 100 |
Tcm | 98 |
Tn | 97 |
γδ | 95 |
Tem | 94 |
NK | 93 |
Teff | 89 |
Treg | 54 |
Stem cell memory (Tscm)
Capability radar
Metric breakdown
Normalized 0–100 educational scores
Cytotoxicity74
Expansion87
Persistence80
Tumor control97
Exhaustion risk10
CRS risk63